Research Team: Itziar Polanco Garriz, Endika de la Iglesia, Ander Miner, Felipe Goñi de Cerio, Alberto Katsumiti
Institution: GAIKER Technology Centre, Basque Research and Technology Alliance (BRTA), Zamudio, Spain
Contact: katsumiti@gaiker.es

This research poster addresses the critical gap in realistic human central nervous system (CNS) models for evaluating nanomaterial neurotoxicity through the iCARE project. The work presents three innovative in vitro model developments: a static blood-brain barrier (BBB) model using cerebral endothelial cells and astrocytes that demonstrates stable barrier formation, advanced 2D and 3D neurotoxicity co-culture systems combining neuron-like cells with microglia, and comprehensive validation studies using graphene materials that show enhanced sensitivity to inflammatory markers and oxidative stress responses compared to traditional single-cell approaches.

View the complete poster by downloading the PDF below.