Research Team: Elise Morel, Monica Martinez, Steve Hodge, James Johnstone, Alberto Katsumiti, Nivedita Chatterjee, Margherita Bernardeschi, Natalia Karczewska, Ernesto Alfaro, James Baker
Institutions: TEMAS Solutions (Switzerland), Avanzare (Spain), Versarien (United Kingdom), Advanced Material Development (United Kingdom), GAIKER (Spain), International Iberian Nanotechnology Laboratory (Portugal), IIT - Smart Bio-Interfaces (Italy), Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

This research poster presents the iCARE project's comprehensive approach to safety testing of advanced materials throughout their complete life cycle. The work addresses critical gaps in transitioning from substance-based to product-based safety assessment by developing integrated neurotoxicity testing methods. Key contributions include establishing performance standards for representative sampling across use and end-of-life phases, adapting regulatory-relevant assays for materials characterization, and creating a predictive screening approach using human and fish cell lines plus invertebrate models to support hazard classification and Safe-by-Design implementation.

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